Symmetrizing The Symmetrization Postulate

Reasonable requirements of (a) physical invariance under particle permutation and (b) physical completeness of state descriptions, enable us to deduce a Symmetric Permutation Rule(SPR): that by taking care with our state descriptions, it is always possible to construct state vectors (or wave functions) that are purely symmetric under pure permutation for all particles, regardless of type distinguishability or spin. The conventional exchange antisymmetry for two identical half-integer spin particles is shown to be due to a subtle interdependence in the individual state descriptions arising from an inherent geometrical asymmetry. For three or more such particles, however, antisymmetrization of the state vector for all pairs simultaneously is shown to be impossible and the SPR makes observably different predictions, although the usual pairwise exclusion rules are maintained. The usual caveat of fermion antisymmetrization - that composite integer spin particles (with fermionic consitituents) behave only approximately like bosons - is no longer necessary.Comment: Paper presented at the Spin2000 Conference in Capri, Italy, May31 - June 3, 2000 Added references and appendi

Conformal ``thin sandwich'' data for the initial-value problem of general relativity

The initial-value problem is posed by giving a conformal three-metric on each of two nearby spacelike hypersurfaces, their proper-time separation up to a multiplier to be determined, and the mean (extrinsic) curvature of one slice. The resulting equations have the {\it same} elliptic form as does the one-hypersurface formulation. The metrical roots of this form are revealed by a conformal ``thin sandwich'' viewpoint coupled with the transformation properties of the lapse function.Comment: 7 pages, RevTe

Buckling strength improvements for Fibre Metal Laminates using thin-ply tailoring

The buckling response and load carrying capacity of thin-walled open cross-section profiles made of Fibre Metal Laminates, subjected to static axial compression loading are considered. These include thin-walled Z-shape and channel cross-section profiles adopting a 3/2 FML lay-up design, made of 3 aluminium layers. The objective of the investigation is the comparison of standard thickness Fibre Reinforced Plastic layers versus thin-ply material technology. Whilst thin ply designs differ only by the layer thickness, they offer an exponential increase in stacking sequence design freedoms, allowing detrimental coupling effects to be eliminated. The benefit of different hybrid materials are also considered. The comparisons involve semi-analytical and finite element methods, which are validated against experimental investigations

Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth.

Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates that these lipid-signaling molecules can have pleiotropic effects on the fate and function of the immune system. These effects range from the regulation of immune cell survival and proliferation to chemotaxis and antiviral immunity. New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic neutrophils into the tumor microenvironment. The consequence of this recruitment is the generation of proangiogenic factors and matrix metalloproteinase proteins that provide a tumor a significant growth and survival advantage. In combination with other recent studies, these data highlight the ongoing cross talk between sterol metabolism and the immune system, and they raise the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic approach in the war on cancer

Geometrical Well Posed Systems for the Einstein Equations

We show that, given an arbitrary shift, the lapse $N$ can be chosen so that the extrinsic curvature $K$ of the space slices with metric $\overline g$ in arbitrary coordinates of a solution of Einstein's equations satisfies a quasi-linear wave equation. We give a geometric first order symmetric hyperbolic system verified in vacuum by $\overline g$, $K$ and $N$. We show that one can also obtain a quasi-linear wave equation for $K$ by requiring $N$ to satisfy at each time an elliptic equation which fixes the value of the mean extrinsic curvature of the space slices.Comment: 13 pages, latex, no figure